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Pasteurisation of a Factor I (C3b Inactivator) Concentrate From Human Plasma

Pasteurisation of a Factor I (C3b Inactivator) Concentrate From Human Plasma

K O Alsøe, J Kihl

Vox Sang. 1989;57(4):240-2.

PMID: 2533430

Abstract:

A method of pasteurising a concentrate of factor I (C3b inactivator) prepared from human blood plasma is described. As well as obtaining a high yield of factor I by this virus inactivation procedure it is furthermore possible, by adjustment of the stabiliser concentration, to obtain a very pronounced reduction in the concentration of factor B, a component of the complement system which is unwanted in the treatment of factor I deficiency. The product so produced is in two respects superior to plasma infusions for factor I replacement therapy: it has been submitted to virus inactivation and factor B depletion.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP80295665	Complement factor I from human plasma		80295-66-5	Price

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