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Patch Testing of Patients Allergic to Disperse Blue 106 and Disperse Blue 124 With Thin-Layer Chromatograms and Purified Dyes

Patch Testing of Patients Allergic to Disperse Blue 106 and Disperse Blue 124 With Thin-Layer Chromatograms and Purified Dyes

Kristina Ryberg, An Goossens, Marléne Isaksson, Birgitta Gruvberger, Erik Zimerson, Lena Persson, Magnus Bruze

Contact Dermatitis. 2009 May;60(5):270-8.

PMID: 19397619

Abstract:

Background:
Former investigations have demonstrated that patch test preparations containing Disperse Blue (DB) 106 and DB 124 are impure.
Objective:
To investigate the significance of impurities in preparations of disperse dyes with regard to contact allergy.
Materials/methods:
21 patients allergic to DB 106 and/or DB 124 were tested with dilution series of commercial and purified DB 106 and DB 124. All patients were additionally tested with thin-layer chromatography (TLC) strips made from the commercial preparations containing DB 106 and 18 of them also with TLC strips containing DB 124.
Results:
13 of 21 and 12/18 patients tested positively to the strips of DB 106 and DB 124, respectively. Among these patients, 4/13 and 5/12, respectively, did not react to the main spot but reacted to other spots. Dilution series of purified DB 106 and DB 124 were positive in 10 patients each, while 16 and 15 patients, respectively, tested positively to the dilution series of the corresponding commercial disperse dye.
Conclusion:
Approximately 25% of the patients, diagnosed as contact allergic to DB 106 and DB 124, only reacted to impurities in the patch test preparations. This has implications for diagnosis and prevention.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP61951517	Disperse Blue 124		61951-51-7	Price

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