Home
Resources
Publications
Patchouli Alcohol: In Vitro Direct Anti-Influenza Virus Sesquiterpene in Pogostemon Cablin Benth

Patchouli Alcohol: In Vitro Direct Anti-Influenza Virus Sesquiterpene in Pogostemon Cablin Benth

Hiroaki Kiyohara, Chikara Ichino, Yuka Kawamura, Takayuki Nagai, Noriko Sato, Haruki Yamada

J Nat Med. 2012 Jan;66(1):55-61.

PMID: 21671149

Abstract:

During the screening of anti-influenza virus substances from traditional herbal medicines, the methanol extract from the leaves of Pogostemon cablin Benth. showed potent in vitro antiviral activity (99.8% inhibition at a concentration of 10 μg/mL) against influenza virus A/PR/8/34 (H1N1). The anti-influenza virus principle was isolated from the hexane-soluble fraction, through solvent fractionation, repeated silica gel column chromatography, and reversed-phase HPLC. The major active principle was a volatile substance that was identified as a sesquiterpene, patchouli alcohol (1), on the basis of its spectral analyses. When anti-influenza virus activity against A/PR/8/34 was evaluated by the plaque forming assay, patchouli alcohol reduced the number of plaques by 75% at 2 μg/mL and 89% at 10 μg/mL. Patchouli alcohol showed dose-dependent anti-influenza virus activity, and its IC(50) value was estimated to be 2.635 μM. Although 11 different sesquiterpenes were tested for antiviral activity against influenza virus A/PR/8/34, no or negligible activity was observed except for patchouli alcohol. Patchouli alcohol did not show anti-influenza virus activity against A/Guizhou/54/89 (H3N2), but showed weak activity against B/Ibaraki/2/85 (IC(50) = 40.82 μM). Patchouli alcohol did not show inhibitory activity against influenza virus neuraminidase.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP5986550	Patchouli alcohol		5986-55-0	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: