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Pattern of Aliphatic Dicarboxylic Acids in Uremic Serum Including a New Organic Acid, 2,4-dimethyladipic Acid

Pattern of Aliphatic Dicarboxylic Acids in Uremic Serum Including a New Organic Acid, 2,4-dimethyladipic Acid

T Niwa, T Ohki, K Maeda, A Saito, K Kobayashi

Clin Chim Acta. 1979 Nov 15;99(1):71-83.

PMID: 498544

Abstract:

(1) 2,4-Dimethyladipic acid was first identified in normal human urine using gas chromatography-mass spectrometry. Urinary excretion of 2,4-dimethyladipic acid in 7 healthy adults ranged from 4.9 mumol to 14 mumol per 24 h. (2) Succinic acid, adipic acid, 3-methyladipic acid, 2,4-dimethyladipic acid, pimelic acid and azelaic acid were identified in the ultrafiltrate of the blood obtained from a chronic uremic patient using a hemodialyzer. (3) Levels of succinic acid, adipic acid, 3-methyladipic acid, 2,4-dimethyladipic acid, pimelic acid and azelaic acid in uremic serum were determined using a mass fragmentographic technique. Concentration of succinic acid in uremic serum was comparable to that in normal serum, whereas concentrations of adipic acid, 3-methyladipic acid, 2,4-dimethyladipic acid, pimelic acid and azelaic acid were highly elevated in uremic serum.

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