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Pd-Catalyzed Thiophene-Aryl Coupling Reaction via C-H Bond Activation in Deep Eutectic Solvents

Angela Punzi, Donato I Coppi, Sergio Matera, Maria A M Capozzi, Alessandra Operamolla, Roberta Ragni, Francesco Babudri, Gianluca M Farinola

Org Lett. 2017 Sep 15;19(18):4754-4757.

PMID: 28876956

Abstract:

Direct arylation of 5-octylthieno[3,4-c]pyrrole-4,6-dione with a series of functionalized aryl iodides via C-H bond activation is demonstrated in a deep eutectic solvent made of choline chloride and urea in non-anhydrous conditions and without exclusion of air. This is the first demonstration of a thiophene-aryl coupling via direct arylation in deep eutectic solvents.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP773881439 5-Octylthieno[3,4-c]pyrrole-4,6-dione 5-Octylthieno[3,4-c]pyrrole-4,6-dione 773881-43-9 Price
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