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Peanut-skin Polyphenols, Procyanidin A1 and epicatechin-(4 β → 6)-epicatechin-(2 β → O → 7, 4 β → 8)-catechin, Exert Cholesterol Micelle-Degrading Activity in Vitro

Peanut-skin Polyphenols, Procyanidin A1 and epicatechin-(4 β → 6)-epicatechin-(2 β → O → 7, 4 β → 8)-catechin, Exert Cholesterol Micelle-Degrading Activity in Vitro

Tomoko Tamura, Naoko Inoue, Megumi Ozawa, Akiko Shimizu-Ibuka, Soichi Arai, Naoki Abe, Hiroyuki Koshino, Kiyoshi Mura

Biosci Biotechnol Biochem. 2013;77(6):1306-9.

PMID: 23748765

Abstract:

We identified epicatechin-(4 β → 6)-epicatechin-(2 β → O → 7, 4 β → 8)-catechin (EEC) in the skin of the peanut (Arachis hypogaea L.). EEC (a trimer) showed more potent cholesterol micelle-degrading activity than procyanidin A1 (a dimer) did in vitro. The hypercholesterolemia suppressing effect of a peanut skin polyphenol on rats fed high-cholesterol diet in our preceding experiments might thus have been due primarily to a micelle degrading effect in the intestine.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP103883030	Procyanidin A1		103883-03-0	Price

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