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Pectolinarigenin, an Aglycone of Pectolinarin, Has More Potent Inhibitory Activities on Melanogenesis Than Pectolinarin

Pectolinarigenin, an Aglycone of Pectolinarin, Has More Potent Inhibitory Activities on Melanogenesis Than Pectolinarin

Sullim Lee, Da-Hye Lee, Jin-Chul Kim, Byung Hun Um, Sang Hyun Sung, Lak Shin Jeong, Yong Kee Kim, Su-Nam Kim

Biochem Biophys Res Commun. 2017 Nov 4;493(1):765-772.

PMID: 28851651

Abstract:

Pectolinarin and pectolinarigenin have been reported to be major compounds in Cirsium setidens. In the present study, we demonstrated inhibitory effects of pectolinarin and pectolinarigenin from C. setidens on melanogenesis. Melanin synthesis was decreased in both pectolinarin- and pectolinarigenin-treated melan-a cells and in a reconstructed human skin model. However, pectolinarigenin treatment showed more potent inhibitory activity of melanin synthesis than did pectolinarin treatment. The concentrations of pectolinarin and pectolinarigenin in C. setidens water extracts were determined by HPLC. Unfortunately, the amount of pectolinarigenin of C. setidens water extract was lower than that of pectolinarin. To increase the pectolinarigenin content in C. setidens water extract, several component conversion methods were studied. Consequently, we identified that microwave irradiation under 1% acetic acid was an optimum sugar elimination method.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP520127	Pectolinarigenin		520-12-7	Price

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