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PEG Based Hyperbranched Polymeric Hollow Nanospheres

PEG Based Hyperbranched Polymeric Hollow Nanospheres

Hongliang Cao, Yixiao Dong, Suzanne O'Rorke, Wenxin Wang, Abhay Pandit

Nanotechnology. 2011 Feb 11;22(6):065604.

PMID: 21212483

Abstract:

The synthesis of a new PEG based hyperbranched copolymer of poly(ethylene glycol) methyl ether methacrylate-co-ethylene glycol dimethacrylate (PEGMEMA-co-EGDMA) was achieved via a one-step in situ deactivation enhanced atom transfer radical polymerization (DE-ATRP). Then, hollow PEG based nanospheres were fabricated from this polymer using a solvent evaporation method and post-stabilisation strategy. Furthermore, the analysis using a cellular metabolic activity assay proved that the copolymer did not affect cellular metabolism, indicating that this PEG based polymeric nanosphere has potential for use in drug delivery applications.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP25777713	Poly(methyl methacrylate-co-ethylene glycol dimethacrylate)		25777-71-3	Price

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