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Penetration of Amoxicillin and Potassium Clavulanate Into the Cerebrospinal Fluid of Patients With Inflamed Meninges

Penetration of Amoxicillin and Potassium Clavulanate Into the Cerebrospinal Fluid of Patients With Inflamed Meninges

J S Bakken, J N Bruun, P Gaustad, T C Tasker

Antimicrob Agents Chemother. 1986 Sep;30(3):481-4.

PMID: 3777911

Abstract:

A single intravenous dose of 2.0 g of amoxicillin and 0.2 g of potassium clavulanate was given to patients with bacterial meningitis, and the pharmacokinetics of both drugs in the cerebrospinal fluid (CSF) and plasma were evaluated. Twenty-one patients aged 14 to 76 years were studied. Both amoxicillin and potassium clavulanate were detectable in the CSF as early as 1 h and reached peak concentrations by approximately 2 h. The highest mean CSF concentrations were 2.25 micrograms/ml for amoxicillin and 0.25 micrograms/ml for potassium clavulanate and were found in patients with moderately or severely inflamed meninges. The CSF penetration relative to plasma for amoxicillin and potassium clavulanate was 5.8 and 8.4%, respectively. These levels suggest that the amoxicillin-potassium clavulanate combination may be effective for the treatment of bacterial meningitis caused by beta-lactamase-producing pathogens.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP61177455	Potassium clavulanate		61177-45-5	Price

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