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Penicillin G as a Novel Chiral Selector in Capillary Electrophoresis

Penicillin G as a Novel Chiral Selector in Capillary Electrophoresis

Shuchi Dixit, Jung Hag Park

J Chromatogr A. 2014 Jan 24;1326:134-8.

PMID: 24373536

Abstract:

The penicillin sub-class of β-lactam antibiotics has not been examined for its enantiodiscriminating abilities in capillary electrophoresis (CE) until date. The present work was therefore designed to evaluate penicillin G potassium salt (PenG) as an ion-pair chiral selector (CS) using CE for its several attributes, namely, high solubility in water and lower alcohols, structure allowing multiple interactions with analytes and cost-effectiveness. Systematic experiments were performed to investigate the effect of composition of background electrolyte, applied voltage and capillary temperature on chiral separation. Baseline resolutions of enantiomers of five basic chiral drugs (namely, darifenacin, citalopram, sertraline, propranolol and metoprolol) were attained using a background electrolyte composed of water:methanol (90:10, v/v) and consisting of 10.7 or 16.1mM CS at 20°C using an applied voltage of 5kV.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP113984-A	Penicillin G potassium salt		113-98-4	Price

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