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Peptides and Polyketides Isolated From the Marine Sponge-Derived Fungus Aspergillus Terreus SCSIO 41008

Xiao-Wei Luo, Yun Lin, Yong-Jun Lu, Xue-Feng Zhou, Yong-Hong Liu

Chin J Nat Med. 2019 Feb;17(2):149-154.

PMID: 30797421

Abstract:

Two new isomeric modified tripeptides, aspergillamides C and D (compounds 1 and 2), together with fifteen known compounds (compounds 3-17), were obtained from the marine sponge-derived fungus Aspergillus terreus SCSIO 41008. The structures of the new compounds, including absolute configurations, were determined by extensive analyses of spectroscopic data (NMR, MS, UV, and IR) and comparisons between the calculated and experimental electronic circular dichroism (ECD) spectra. Butyrolactone I (compound 11) exhibited strong inhibitory effects against Mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB) with the IC50 being 5.11 ± 0.53 μmol·L-1, and acted as a noncompetitive inhibitor based on kinetic analysis.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP87414491 Butyrolactone I - CAS 87414-49-1 Butyrolactone I - CAS 87414-49-1 87414-49-1 Price
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