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Percutaneous Absorption of Flufenamic Acid in Rabbits: Effect of Dimethyl Sulfoxide and Various Nonionic Surface-Active Agents

C C Hwang, A G Danti

J Pharm Sci. 1983 Aug;72(8):857-60.

PMID: 6620136

Abstract:

Eight nonionic surface-active agents were each incorporated at a concentration of 10% into a white petrolatum ointment base containing 10% flufenamic acid with or without dimethyl sulfoxide. Percutaneous absorption was studied by determining the plasma concentration of flufenamic acid in New Zealand White rabbits at regular intervals for 8 hr following application of the ointment. The percutaneous absorption of flufenamic acid was significantly increased when sorbitan trioleate, polyoxyl 8 stearate, or polyoxyethylene 2 oleyl ether were added to the ointment containing flufenamic acid and white petrolatum. The percutaneous absorption of flufenamic acid was increased significantly when sorbitan monopalmitate, sorbitan trioleate, polyoxyl 8 stearate, polyoxyethylene 20 cetyl ether, or polyoxyethylene 2 oleyl ether were added to the ointment containing dimethylsulfoxide, flufenamic acid, and white petrolatum.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP9004993-E Polyoxyl 8 stearate Polyoxyl 8 stearate 9004-99-3 Price
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