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Percutaneous Absorption of Salicylic Acid After Administration of Trolamine Salicylate Cream in Rats With transcutol(®) and Eucalyptus Oil Pre-Treated Skin

Percutaneous Absorption of Salicylic Acid After Administration of Trolamine Salicylate Cream in Rats With transcutol(®) and Eucalyptus Oil Pre-Treated Skin

Paniz Sajjadi, Mohammad Javad Khodayar, Behzad Sharif Makhmalzadeh, Saeed Rezaee

Adv Pharm Bull. 2013;3(2):295-301.

PMID: 24312851

Abstract:

Purpose:
This study was conducted to assess the effect of skin pre-treatment with Transcutol(®) and eucalyptus oil on systemic absorption of topical trolamine salicylate in rat.
Methods:
Pharmacokinetic parameters of salicylic acid following administration of trolamine salicylate on rat skin pre-treated with either Transcutol(®) or eucalyptus oil were determined using both non-compartmental and non-linear mixed effect modeling approaches and compared with those of control group.
Results:
Median (% of interquartile range/median) of salicylic acid AUC0-8hr (ng/mL/hr) values in Transcutol(®) or eucalyptus oil treated rats were 2522(139%) and 58976(141%), respectively as compared to the 3023(327%) of the control group. Skin pre-treatment with eucalyptus oil could significantly decrease extravascular volume of distribution (V/F) and elimination rate constant (k) of salicylic acid.
Conclusion:
Unlike Transcutol(®), eucalyptus oil lead to enhanced transdermal absorption of trolamine salicylate through rat skin.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP2174165	Trolamine salicylate		2174-16-5	Price

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