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Peripheral Toxicity of hemicholinium-3 in Mice

Peripheral Toxicity of hemicholinium-3 in Mice

J J Freeman, J W Kosh, J S Parrish

Br J Pharmacol. 1982 Oct;77(2):239-44.

PMID: 7139185

Abstract:

1 The site (i.e. peripheral or central) of the toxicity produced by hemicholinium-3 in mice was investigated. 2 Hemicholinium-3 was measured fluorometrically and acetylcholine was determined by gas chromatography after intraventricular or intraperitoneal administration of hemicholinium-3. 3 Hemicholinium-3 was not detected in the brain nor were acetylcholine levels decreased in the brain after systemic administration. 4 The dose-response curve following intraventricular administration demonstrated that hemicholinium-3 was not as lethal after central administration as it was after peripheral administration. 5 Approximately 24% of a 75 microgram intraventricular dose of hemicholinium-3 was found in the periphery at death. 6 These results suggest that hemicholinium-3 manifests its toxicity primarily in the periphery.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP312458	Hemicholinium-3		312-45-8	Price

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