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Perlapine: Relationship Between Stimulation of Prolactin Secretion and Antipsychotic Activity

H Y Meltzer, R G Fessler, V S Fang

Psychopharmacology (Berl). 1977 Oct 20;54(2):183-6.

PMID: 412213

Abstract:

Perlapine is a dibenzohetereopine compound chemically related to clothiapine, loxapine, and clozapine. Although the latter three compounds are antipsychotic, perlapine has not been reported to be antipsychotic. Nevertheless, all four drugs increase rat plasma prolactin levels. The order of potency is loxapine, perlapine, clothiapine, and clozapine. These results suggest that either perlapine should be reexamined for antipsychotic properties or there are hitherto unsuspected discrepancies between the dopamine receptors relevant to antipsychotic activity in man and those that regulate prolactin secretion in the rat.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP1977113 Perlapine Perlapine 1977-11-3 Price
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