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Permeability of Anti-Fouling PEGylated Surfaces Probed by Fluorescence Correlation Spectroscopy

Permeability of Anti-Fouling PEGylated Surfaces Probed by Fluorescence Correlation Spectroscopy

Charlisa R Daniels, Carmen Reznik, Rachel Kilmer, Mary Jane Felipe, Maria Celeste R Tria, Katerina Kourentzi, Wen-Hsiang Chen, Rigoberto C Advincula, Richard C Willson, Christy F Landes

Colloids Surf B Biointerfaces. 2011 Nov 1;88(1):31-8.

PMID: 21742471

Abstract:

The present work reports on in situ observations of the interaction of organic dye probe molecules and dye-labeled protein with different poly(ethylene glycol) (PEG) architectures (linear, dendron, and bottle brush). Fluorescence correlation spectroscopy (FCS) and single molecule event analysis were used to examine the nature and extent of probe-PEG interactions. The data support a sieve-like model in which size-exclusion principles determine the extent of probe-PEG interactions. Small probes are trapped by more dense PEG architectures and large probes interact more with less dense PEG surfaces. These results, and the tunable pore structure of the PEG dendrons employed in this work, suggest the viability of electrochemically-active materials for tunable surfaces.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
LS76205	Poly(ethylene glycol) linear dendron, PEG Mn 2000, generation 1			Price

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