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Persistent Oral Dyskinesias in Haloperidol-Withdrawn Neonatal 6-hydroxydopamine-lesioned Rats

Persistent Oral Dyskinesias in Haloperidol-Withdrawn Neonatal 6-hydroxydopamine-lesioned Rats

N Y Huang, R M Kostrzewa

Eur J Pharmacol. 1994 Dec 27;271(2-3):433-7.

PMID: 7705443

Abstract:

Because chronic haloperidol-treated rats demonstrate an increased incidence of spontaneous oral activity, while neonatal 6-hydroxydopamine-lesioned rats demonstrate an increased incidence of dopamine agonist-induced oral activity, we studied the influence of haloperidol in 6-hydroxydopamine-lesioned rats. At 3 days after birth rats received 6-hydroxydopamine hydrobromide (200 micrograms intracerebroventricularly; desipramine pretreatment, 20 mg/kg i.p., 1 h) or vehicle. Two months later haloperidol (1.5 mg/kg per day x 2 days per week, for 4 weeks; then 1.5 mg/kg per day, every day for 10 months) was added to the drinking water. After 15 weeks the level of spontaneous oral activity was stable. At 11 months there were 35.8 +/- 4.9 vs. 18.4 +/- 2.1 oral movements in 6-hydroxydopamine-lesioned vs. intact rats receiving haloperidol. This effect persisted unabated in lesioned rats for 4 months after haloperidol withdrawal. This stable high frequency of oral dyskinesias is an advantage for studying putative therapeutic drugs for tardive dyskinesia.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP636000	6-Hydroxydopamine hydrobromide		636-00-0	Price

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