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PET Imaging of Bacterial Infections With fluorine-18-labeled Maltohexaose

PET Imaging of Bacterial Infections With fluorine-18-labeled Maltohexaose

Xinghai Ning, Wonewoo Seo, Seungjun Lee, Kiyoko Takemiya, Mohammad Rafi, Xuli Feng, Daiana Weiss, Xiaojian Wang, Larry Williams, Vernon M Camp, Malveaux Eugene, W Robert Taylor, Mark Goodman, Niren Murthy

Angew Chem Int Ed Engl. 2014 Dec 15;53(51):14096-14101.

PMID: 25330976

Abstract:

A positron emission tomography (PET) tracer composed of (18)F-labeled maltohexaose (MH(18)F) can image bacteria in vivo with a sensitivity and specificity that are orders of magnitude higher than those of fluorodeoxyglucose ((18)FDG). MH(18)F can detect early-stage infections composed of as few as 10(5) E. coli colony-forming units (CFUs), and can identify drug resistance in bacteria in vivo. MH(18)F has the potential to improve the diagnosis of bacterial infections given its unique combination of high specificity and sensitivity for bacteria.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP34620774	Maltohexaose		34620-77-4	Price

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