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pH Responsive Controlled Release of Anti-Cancer Hydrophobic Drugs From Sodium Alginate and Hydroxyapatite Bi-Coated Iron Oxide Nanoparticles

pH Responsive Controlled Release of Anti-Cancer Hydrophobic Drugs From Sodium Alginate and Hydroxyapatite Bi-Coated Iron Oxide Nanoparticles

Danushika C Manatunga, Rohini M de Silva, K M Nalin de Silva, Nuwan de Silva, Shiva Bhandari, Yoke Khin Yap, N Pabakara Costha

Eur J Pharm Biopharm. 2017 Aug;117:29-38.

PMID: 28330763

Abstract:

Developing a drug carrier system which could perform targeted and controlled release over a period of time is utmost concern in the pharmaceutical industry. This is more relevant when designing drug carriers for poorly water soluble drug molecules such as curcumin and 6-gingerol. Development of a drug carrier system which could overcome these limitations and perform controlled and targeted drug delivery is beneficial. This study describes a promising approach for the design of novel pH sensitive sodium alginate, hydroxyapatite bilayer coated iron oxide nanoparticle composite (IONP/HAp-NaAlg) via the co-precipitation approach. This system consists of a magnetic core for targeting and a NaAlg/HAp coating on the surface to accommodate the drug molecules. The nanocomposite was characterized using FT-IR spectroscopy, X-ray diffraction, scanning electron microscopy, transmission electron microscopy and thermogravimetric analysis. The loading efficiency and loading capacity of curcumin and 6-gingerol were examined. In vitro drug releasing behavior of curcumin and 6-gingerol was studied at pH 7.4 and pH 5.3 over a period of seven days at 37°C. The mechanism of drug release from the nanocomposite of each situation was studied using kinetic models and the results implied that, the release is typically via diffusion and a higher release was observed at pH 5.3. This bilayer coated system can be recognized as a potential drug delivery system for the purpose of curcumin and 6-gingerol release in targeted and controlled manner to treat diseases such as cancer.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP13463439	Iron(II) sulfate hydrate		13463-43-9	Price

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