Home
Resources
Publications
Pharmacokinetic Investigation on Interaction Between Hydrophilic Lithospermic Acid B and Lipophilic Tanshinone IIA in Rats: An Experi- Mental Study

Pharmacokinetic Investigation on Interaction Between Hydrophilic Lithospermic Acid B and Lipophilic Tanshinone IIA in Rats: An Experi- Mental Study

Wang Xiuli, Gao Wei, Sun Mao

J Tradit Chin Med. 2015 Apr;35(2):206-10.

PMID: 25975054

Abstract:

Objective:
To elucidate the interaction between hydrophilic lithospermic acid B and lipophilic tanshinone II A in rats.
Methods:
A reliable high-performance liquid chromatography method was adopted for simultaneous determination of lithospermic acid B and tanshinone II A in rat plasma, through which the pharmacokinetic interaction between lithospermic acid B and tanshinone II A by intravenous injection was investigated.
Results:
The simultaneous intravenous injection of tanshinone II A and lithospermic acid B significantly altered the pharmacokinetic parameters of both compounds when compared with the individual intravenous administration of each compound. The area under the concentration-time curve of tanshinone II A and lithospermic acid B increased by 18.35 and 59.31%, respectively. The mean retention time of tanshinone II A and lithospermic acid B increased, respectively, from 9.3 to 32.8 h and 20.2 to 49.1 h. The concomitant use of tanshinone II A magnified the volume of distribution at steady state (Vss) and time for the drug in the plasma to reduce the highest concentration by half (t½) of lithospermic acid B, while at the same time the Vss and t½ of tanshinone II A changed significantly in the presence of lithospermic acid B.
Conclusion:
Lithospermic acid B and tanshinone II A interact with each other following simultaneous intravenous injection in rats and this observation may expand the clinical use of Danshen (Radix Salviae Miltiorrhizae).

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP28831654	Lithospermic acid		28831-65-4	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: