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Pharmacokinetic Study of Rosavin in Rat Plasma With Ultra Performance LC-MS/MS After Intravenous and Gavage Administration

Pharmacokinetic Study of Rosavin in Rat Plasma With Ultra Performance LC-MS/MS After Intravenous and Gavage Administration

Manman Zhang, Zhiyan Hu, Bingqing Fang, Xiujie Bao, Zheng Xiang, Haixing Wang

Bioanalysis. 2019 May;11(9):837-845.

PMID: 31094215

Abstract:

Aim: A sensitive and selective ultra performance LC-MS/MS (UPLC-MS/MS) method was developed to investigate the pharmacokinetics of rosavin as a potential adaptogenic drug isolated from Rhodiola rosa L. in rat plasma with salidroside as an internal standard. Methodology: Chromatographic separation was performed on a UPLC HSS T3 column (1.8 μm, 100 mm × 2.1 mm) with gradient elution. Multiple reaction monitoring was employed for MS analysis. Rosavin and salidroside were determined with multiple reaction monitoring-ion transitions m/z 427.2 → 293.1 and m/z 299.1 → 119.1, respectively. Conclusion: The validated UPLC-MS/MS method showed a satisfied linear range in 5-5000 ng/ml-1 and was successfully applied for the pharmacokinetic study of rosavin in the rat after intravenous and gavage administration.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP84954927	Rosavin		84954-92-7	Price

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