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Pharmacokinetic Study of Salvianolic Acid D After Oral and Intravenous Administration in Rats

Pharmacokinetic Study of Salvianolic Acid D After Oral and Intravenous Administration in Rats

Junke Song, Wen Zhang, Jialin Sun, Xiaona Xu, Xue Zhang, Li Zhang, Zhangying Feng, Guan-Hua Du

Acta Pharm Sin B. 2015 May;5(3):246-53.

PMID: 26579453

Abstract:

A sensitive, specific and rapid LC-MS method was developed and validated for the determination of salvianolic acid D (SalD) in rat plasma. This method used a single quadrupole mass spectrometer with an electrospray ionization (ESI) source. A single ion monitoring scanning (SIM) mode was employed. It showed good linearity over the concentration range from 3.3 to 666.7 ng/mL for the determination of SalD. The R.S.D.% of intra-day and inter-day precision values were no more than 7.69%, and the accuracy was within 91%-104% at all quality control levels. This LC-MS method was applied to the pharmacokinetic study of SalD in rats. A two-compartmental model analysis was employed. The plasma concentrations at 2 min (C 2min) were 5756.06±719.61, 11,073.01±1783.46 and 21,077.58±5581.97 μg/L for 0.25, 0.5 and 1 mg/kg intravenous injection, respectively. The peak plasma concentration (C max) was 333.08±61.21 μg/L for 4 mg/kg oral administration. The area under curve (AUC0-t ) was 14,384.379±8443.184, 22,813.369±11,860.823, 46,406.122±27,592.645 and 8201.740±4711.961 μg/L·h for intravenous injection (0.25, 0.5 and 1 mg/kg) and oral administration (4 mg/kg), respectively. The bioavailability of SalD was calculated to be 4.159%±0.517%.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP142998478	Salvianolic acid D		142998-47-8	Price

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