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Pharmacokinetics and Distribution of Schisandrol A and Its Major Metabolites in Rats

Pharmacokinetics and Distribution of Schisandrol A and Its Major Metabolites in Rats

Xu Liu, Lixin Cong, Chunmei Wang, He Li, Chengyi Zhang, Xingang Guan, Peng Liu, Yu Xie, Jianguang Chen, Jinghui Sun

Xenobiotica. 2019 Mar;49(3):322-331.

PMID: 29251086

Abstract:

1. Schizandrol A is an active component in schisandra, also the representative component for the identification of schisandra. 2. A rapid resolution liquid chromatography coupled with quadruple-time-of-flight mass spectrometry (RRLC-QTOF/MS) was developed to investigate the pharmacokinetics of schizandrol A after its intragastric administration (50 mg/kg) in rats. 3. Schizandrol A was rapidly absorbed (T max = 2.07 h), with a longer duration (t 1/2 = 9.48 h) and larger apparent volume of distribution (Vz/F = 111.81 l/kg) in rats. Schizandrol A can be detected in main organs and the order of its distribution was in the liver > kidney > heart > spleen > brain, particularly higher in the liver. 4. Five schizandrol A metabolites were identified, including 2-demethyl-8(R)-hydroxyl-schizandrin, 3-demethyl-8(R)-hydroxyl-schizandrin, hydroxyl-schizandrin, demethoxy-schizandrin, 2, 3-demethyl-8(R)-hydroxyl-schizandrin, indicating that the hydroxylation and demethylation may be the major metabolic way of schizandrol A. 5. This study defined the pharmacokinetic characteristics of schizandrol A in vivo, and the RRLC-QTOF/MS is more sensitive and less limited by conditions, and needs less samples, which may be a useful resource for the further research and development of schisandrol A.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP7432282-A	Schisandrol A		7432-28-2	Price

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