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[Pharmacokinetics and Relative Bioavailability of Neostigmine Bromide Sustained-Release Tablets]

[Pharmacokinetics and Relative Bioavailability of Neostigmine Bromide Sustained-Release Tablets]

Hua-Rong Xiong, Qun-You Tan, Bi-Lin Liu, Wen Luo, Jing-Qing Zhang

Sichuan Da Xue Xue Bao Yi Xue Ban. 2011 Sep;42(5):657-60.

PMID: 22007493

Abstract:

Objective:
To study the pharmacokinetics and relative bioavailability of neostigmine bromide conventional tablets and sustained-release tablets in rabbits.
Methods:
Six healthy rabbits were randomly divided into two groups for a cross self-contrast trial. RP-HPLC was used to detect plasma concentrations of neostigmine bromide. The pharmacokinetic parameters were calculated with the aid of DAS 2.0 software.
Results:
The main pharmacokinetics parameters of the sustained-release tablets and conventional tablets were as follows, respectively: T(max)(3.67 +/- 1.51) hand (1.58 +/- 0.38) h; C(max) (5.04 +/- 1.19) mg/L and (4.56 +/- 1.70) mg/L; AUC(0 --> infinity) (32.82 +/- 9.88) mg/L x h and (29.84 +/- 14.27) mg/L x h. The relative bioavailability of the neostigmine bromide sustained-release tablets was 115.4%.
Conclusion:
The pharmacokinetics of neostigmine bromide accords with two compartments model, showing constant plasma concentration and relatively high bioavailability.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP114807-A	Neostigmine bromide		114-80-7	Price

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