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Pharmacokinetics of 23-epi-26-deoxyactein in Women After Oral Administration of a Standardized Extract of Black Cohosh

Pharmacokinetics of 23-epi-26-deoxyactein in Women After Oral Administration of a Standardized Extract of Black Cohosh

R B van Breemen, W Liang, S Banuvar, L P Shulman, Y Pang, Y Tao, D Nikolic, K M Krock, D S Fabricant, S-N Chen, S Hedayat, J L Bolton, G F Pauli, C E Piersen, E C Krause, S E Geller, N R Farnsworth

Clin Pharmacol Ther. 2010 Feb;87(2):219-25.

PMID: 20032972

Abstract:

Dietary supplements containing black cohosh are alternatives to conventional hormone replacement therapy in menopause. This study investigates the maximum tolerated dose of a 75% ethanol extract of black cohosh and determines the pharmacokinetics of one of its most abundant triterpene glycosides, 23-epi-26-deoxyactein. Single doses of black cohosh extract containing 1.4, 2.8, or 5.6 mg of 23-epi-26-deoxyactein were administered to 15 healthy, menopausal women. Serial blood samples and 24-h urine samples were obtained; blood chemistry, hormonal levels, and 23-epi-26-deoxyactein levels were determined. No acute toxicity or estrogenic hormone effects were observed. Pharmacokinetic analyses of 23-epi-26-deoxyactein in sera indicated that the maximum concentration and area under the curve increased proportionately with dosage, and that the half-life was ~2 h for all dosages. Less than 0.01% of the 23-epi-26-deoxyactein was recovered in urine 24 h after administration. No phase I or phase II metabolites were observed either in clinical specimens or in vitro.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP501938018	23-epi-26-Deoxyactein		501938-01-8	Price

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