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Pharmacokinetics of Antipyrine in Epileptic Patients

Pharmacokinetics of Antipyrine in Epileptic Patients

E M Rimmer, P A Routledge, L M Tsanaclis, A Richens

Br J Clin Pharmacol. 1986 May;21(5):511-4.

PMID: 3718808

Abstract:

The pharmacokinetics of antipyrine were examined after oral and intravenous administration to 20 epileptic subjects receiving antiepileptic drug therapy. Bioavailability was essentially complete (mean bioavailability 101.2% +/- 14.4 (s.d.] indicating that even in enzyme induced subjects, antipyrine behaves as a restrictively eliminated compound with negligible presystemic elimination in the gut or liver. Of the generally used measures of enzyme induction (oral clearance, oral half-life and intravenous half-life) oral clearance was the most closely related to the intravenous clearance of antipyrine (r = 0.919, P less than 0.001). Oral antipyrine administration is an alternative to intravenous administration in epileptic subjects who are enzyme-induced.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP89258	Antipyrine Related Compound A		89-25-8	Price

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