Home
Resources
Publications
Pharmacokinetics of Hederacoside C, an Active Ingredient in AG NPP709, in Rats

Pharmacokinetics of Hederacoside C, an Active Ingredient in AG NPP709, in Rats

Ju Myung Kim, Ji Na Yoon, Ji Won Jung, Hye Duck Choi, Young June Shin, Chang Kyun Han, Hye Suk Lee, Hee Eun Kang

Xenobiotica. 2013 Nov;43(11):985-92.

PMID: 23607546

Abstract:

1. Hederacoside C (HDC) is one of the active ingredients in Hedera helix leaf extract (Ivy Ex.) and AG NPP709, a new botanical drug to treat acute respiratory infection and chronic inflammatory bronchitis. However, information regarding its pharmacokinetic properties remains limited. 2. Here, we report the pharmacokinetics of HDC in rats after intravenous administration of HDC (3, 12.5, and 25 mg/kg) and after oral administration of HDC, Ivy Ex., and AG NPP709 (equivalent to 12.5, 25, and 50 mg/kg HDC). 3. Linear pharmacokinetics of HDC were identified upon its intravenous administration at doses of 3-25 mg/kg. Intravenous administration of HDC results in relatively slow clearance (1.46-2.08 mL/min/kg) and a small volume of distribution at steady state (138-222 mL/kg), while oral administration results in a low absolute oral bioavailability (F) of 0.118-0.250%. The extremely low F of HDC may be due to poor absorption of HDC from the gastrointestinal (GI) tract and/or its decomposition therein. 4. The oral pharmacokinetics of HDC did not differ significantly among pure HDC, Ivy Ex., and AG NPP709.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP14216036	Hederacoside C		14216-03-6	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: