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Pharmacokinetics of Metronidazole and Its Major Metabolite After a High Intravenous Dose

Pharmacokinetics of Metronidazole and Its Major Metabolite After a High Intravenous Dose

T Bergan, S Aase, O Leinebo, T Harbitz, A Olsen, I Liavag

Scand J Gastroenterol Suppl. 1984;91:113-23.

PMID: 6588488

Abstract:

The pharmacokinetics of metronidazole (M) and hydroxy-metronidazole (OH-M) were determined in 8 healthy volunteers after a single dose of 1.5 g metronidazole given as an intravenous infusion during 50 min. High-pressure liquid chromatography was used for the assays. The serum concentration determined 1 h after the start of infusion was 40.21 +/- 6.54 mg/1. The peak concentrations of the metabolite were observed after 8-12 h. The serum concentrations of M and OH-M were detectable throughout the 48 h monitored. The serum half-life of M was 7.6 h and of OH-M 13.3 h. The terminal phase distribution volume was 43.2 lit and the total body clearance 4.0 lit./h. The prophylactic use of 1.5 g of metronidazole given as a single intravenous dose 1 h prior to surgery is supported by the pharmacokinetic assessments in this study.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP4812402	Metronidazole-OH		4812-40-2	Price

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