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Pharmacokinetics of Penicillin G Procaine Versus Penicillin G Potassium and Procaine Hydrochloride in Horses

Pharmacokinetics of Penicillin G Procaine Versus Penicillin G Potassium and Procaine Hydrochloride in Horses

C E Uboh, L R Soma, Y Luo, E McNamara, M A Fennell, L May, D C Teleis, J A Rudy, A O Watson

Am J Vet Res. 2000 Jul;61(7):811-5.

PMID: 10895905

Abstract:

Objective:
To compare the pharmacokinetics of penicillin G and procaine in racehorses following i.m. administration of penicillin G procaine (PGP) with pharmacokinetics following i.m. administration of penicillin G potassium and procaine hydrochloride (PH).
Animals:
6 healthy adult mares.
Procedure:
Horses were treated with PGP (22,000 units of penicillin G/kg of body weight, i.m.) and with penicillin G potassium (22,000 U/kg, i.m.) and PH (1.55 mg/kg, i.m.). A minimum of 3 weeks was allowed to elapse between drug treatments. Plasma and urine penicillin G and procaine concentrations were measured by use of high-pressure liquid chromatography.
Results:
Median elimination phase half-lives of penicillin G were 24.7 and 12.9 hours, respectively, after administration of PGP and penicillin G potassium. Plasma penicillin G concentration 24 hours after administration of penicillin G potassium and PH was not significantly different from concentration 24 hours after administration of PGP. Median elimination phase half-life of procaine following administration of PGP (15.6 hours) was significantly longer than value obtained after administration of penicillin G potassium and PH (1 hour).
Conclusions and clinical relevance:
Results suggest that i.m. administration of penicillin G potassium will result in plasma penicillin G concentrations for 24 hours after drug administration comparable to those obtained with administration of PGP Clearance of procaine from plasma following administration of penicillin G potassium and PH was rapid, compared with clearance following administration of PGP.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP6130649	Penicillin G procaine		6130-64-9	Price

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