Home
Resources
Publications
Pharmacological Action of FPL 55712 on Canine Cerebral Arterial Segments

Pharmacological Action of FPL 55712 on Canine Cerebral Arterial Segments

T Sasaki, N F Kassell, D M Turner, Y G Comair, M Yamashita, S Fujiwara

Acta Neurochir (Wien). 1985;74(1-2):81-3.

PMID: 3856380

Abstract:

The pharmacological action of a leukotriene antagonist FPL 55712 was studied on canine cerebral arterial segments. FPL 55712 at concentrations of 10(-6)M and 10)-5)M showed dose-dependent inhibition of the constrictor responses of the artery to prostaglandin F2 alpha. The constrictor responses of the artery to either serotonin or haemoglobin were suppressed by 10(-5)M FPL 55712, while 10(-6)M FPL 55712 failed to alter the responses. The KCL-induced constriction was not affected by treatment with either 10(-6)M or 10(-5)M FPL 55712. The present results suggest that FPL 55712 has vasodilator properties other than those related to the inhibition of leukotrienes.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP40786081	FPL-55712		40786-08-1	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: