Home
Resources
Publications
Pharmacological Analysis of the Cardiac Sympatho-Inhibitory Actions of Moxonidine and Agmatine in Pithed Spontaneously Hypertensive Rats

Pharmacological Analysis of the Cardiac Sympatho-Inhibitory Actions of Moxonidine and Agmatine in Pithed Spontaneously Hypertensive Rats

Luis E Cobos-Puc, Araceli Sánchez-López, David Centurión

Eur J Pharmacol. 2016 Nov 15;791:25-36.

PMID: 27565220

Abstract:

This study shows that in spontaneously hypertensive rats (SHR) of 14-weeks-old, the sympathetically-induced, but not noradrenaline-induced tachycardic response are higher than age-matched Wistar normotensive rats. Furthermore, in SHR the sympathetically-induced tachycardic response was: (1) unaffected by moxonidine (3μg/kgmin); (2) partially inhibited by B-HT 933 (30μg/kgmin), both at the lowest doses; and (3) completely inhibited by the highest doses of B-HT 933 (100μg/kgmin), moxonidine (10μg/kgmin) or agmatine (1000 and 3000μg/kgmin) while the noradrenaline-induced tachycardic responses remained unaffected by the above compounds, except by 3000μg/kgmin agmatine. In SHR, 300μg/kg rauwolscine failed to block the sympatho-inhibition to 100μg/kgmin B-HT 933 or 10μg/kgmin moxonidine, but 1000μg/kg rauwolscine abolished, partially antagonized, and did not modify the sympatho-inhibition to the highest doses of B-HT 933, moxonidine, and agmatine, respectively, 3000μg/kg AGN 192403 or 300μg/kg BU224 given alone had no effect in the moxonidine- or agmatine-induced sympatho-inhibition, and the combination rauwolscine plus AGN 192403 but not plus BU224, abolished the sympatho-inhibition to the highest doses of moxonidine and agmatine. In conclusion, the sympathetically-induced tachycardic responses in SHR are inhibited by moxonidine and agmatine. The inhibition of moxonidine is mainly mediated by prejunctional α2-adrenoceptors and to a lesser extent by I1-imidazoline receptors, while the inhibition of agmatine is mediated by prejunctional α2-adrenoceptors and I1-imidazoline receptors at the same extent. Notwithstanding, the inhibitory function of α2-adrenoceptors seems to be altered in SHR compared with Wistar normotensive rats.

Chemicals Related in the Paper:

Catalog Number	Product Name	CAS Number	Price
AP2482000	Agmatine sulfate salt	2482-00-0	Price
AP3414639	(±)-Norepinephrine (+)-bitartrate salt	3414-63-9	Price
IAR4241986	Moxonidine hydrochloride		Price
IAR4242387	BU224 hydrochloride		Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: