Home
Resources
Publications
Phenolic Compounds From Miconia Myriantha Inhibiting Candida Aspartic Proteases

Phenolic Compounds From Miconia Myriantha Inhibiting Candida Aspartic Proteases

X C Li, M R Jacob, D S Pasco, H N ElSohly, A C Nimrod, L A Walker, A M Clark

J Nat Prod. 2001 Oct;64(10):1282-5.

PMID: 11678651

Abstract:

Assay-guided fractionation of the ethanol extract of the twigs and leaves of Miconia myriantha yielded two new compounds, mattucinol-7-O-[4' ',6' '-O-(S)-hexahydroxydiphenoyl]-beta-D-glucopyranoside (1) and mattucinol-7-O-[4' ',6' '-di-O-galloyl]-beta-D-glucopyranoside (2), along with mattucinol-7-O-beta-D-glucopyranoside (3), ellagic acid (4), 3,3'-di-O-methyl ellagic acid-4-O-beta-D-xylopyranoside, and gallic acid. Complete (1)H and (13)C NMR assignments of compound 1, which possesses a hexahydroxydiphenoyl unit, were achieved using the HMBC technique optimized for small couplings to enhance the four-bond and two-bond H/C correlations. Compounds 1 and 4 showed inhibitory effects against Candida albicans secreted aspartic proteases, with IC(50) of 8.4 and 10.5 microM, respectively.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP62218239	3,3′-Di-O-methyl ellagic acid 4′-O-β-D-xylopyranoside		62218-23-9	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: