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Phenosafranin Inhibits Nuclear Localization of Transglutaminase 2 Without Affecting Its Transamidase Activity

Yutaka Furutani, Mariko Toguchi, Rajan Shrestha, Soichi Kojima

Amino Acids. 2017 Mar;49(3):483-488.

PMID: 27665106

Abstract:

Transglutaminase 2 (TG2) localizes to the nucleus and induces apoptosis through a crosslinking inactivation of Sp1 in JHH-7 cells treated with acyclic retinoid. We screened an inhibitor suppressing transamidase activity in the nucleus without affecting transamidase activity itself. Phenosafranin was found to inhibit nuclear localization of EGFP-tagged TG2 and dose-dependently reduce nuclear transamidase activity without affecting the activity in a tube. We concluded that phenosafranin was a novel TG2 inhibitor capable of suppressing its nuclear localization.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP81936 Phenosafranin Phenosafranin 81-93-6 Price
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