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Phorbol-12-myristate-13-acetate (PMA) Mediated Transcriptional Regulation of Oncostatin-M

Phorbol-12-myristate-13-acetate (PMA) Mediated Transcriptional Regulation of Oncostatin-M

Srimoyee Mukherjee, Sumita Sengupta Bandyopadhyay

Cytokine. 2016 Dec;88:209-213.

PMID: 27676154

Abstract:

Oncostatin-M (OSM), an IL-6 family cytokine, exhibits varied roles in different patho-physiological conditions. Differential expression of OSM in response to varying stimuli indicates importance of its regulation of expression. The present study illustrated transcriptional induction of osm on treatment with chemical inducer, phorbol-12-myristate-13-acetate (PMA). Following initial hours of PMA treatment, a nuclear protein C/EBP-β binds specifically to the CCAAT consensus sequence at the proximal end of the OSM promoter. Genistein (a specific Tyr phosphorylation inhibitor) leads to the interaction of CHOP (C/EBP Homologous Protein) with C/EBP-β, thus negatively regulating it. Knockdown of C/EBP-β also leads to inhibition of PMA-mediated OSM induction.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP16561298-A	Phorbol 12-myristate 13-acetate		16561-29-8	Price

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