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Phosphate Radical Induced Oxidation of Pyrimidine Bases in Aqueous Solution

Phosphate Radical Induced Oxidation of Pyrimidine Bases in Aqueous Solution

M R Kumar, M T Rao, M Adinarayana

Indian J Biochem Biophys. 2000 Feb;37(1):13-7.

PMID: 10983408

Abstract:

The photooxidation of pyrimidine bases viz., uracil and cytosine in presence of peroxydiphosphate (PDP) in aqueous solution at natural pH (approximately 7.5) has been carried out in a quantum yield reactor using a high-pressure mercury lamp. The rates of oxidation and quantum yields of pyrimidine oxidation have been found to increase with increase in [PDP] while they are independent of [pyrimidine] and light intensity. On the basis of these experimental results, product analysis and existence of isosbestic points a probable mechanism is suggested in which peroxydiphosphate ion on photolysis gives phosphate radical anions which initiates the reaction by adding to C(5) or C(6) of pyrimidine base leading to the formation of pyrimidine radical via radical cation or hydrolysis. This further reacts with PDP and gives the final products 5,6-dihydroxy pyrimidine and isobarbituric acid.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP496764-A	Isobarbituric acid		496-76-4	Price

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