Home
Resources
Publications
Phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ), a Lipid Signalling Enigma

Phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ), a Lipid Signalling Enigma

Maria-Luisa Giudici, Jonathan H Clarke, Robin F Irvine

Adv Biol Regul. 2016 May;61:47-50.

PMID: 26710750

Abstract:

The phosphatidylinositol 5-phosphate 4-kinases (PI5P4Ks) are an important family of enzymes, whose physiological roles are being teased out by a variety of means. Phosphatidylinositol-5-phosphate 4-kinase γ (PI5P4Kγ) is especially intriguing as its in vitro activity is very low. Here we review what is known about this enzyme and discuss some recent advances towards an understanding of its physiology. Additionally, the effects of the ATP-competitive inhibitor I-OMe Tyrphostin AG-538 on all three mammalian PI5P4Ks was explored, including two PI5P4Kγ mutants with altered ATP- or PI5P-binding sites. The results suggest a strategy for targeting non-ATP binding sites on inositol lipid kinases.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR4245438	I-OMe-Tyrphostin AG 538			Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: