0

Phosphonoacetic Acid-Resistant Mutants of Herpes Simplex Virus: Effect of Phosphonoacetic Acid on Virus Replication and in Vitro Deoxyribonucleic Acid Synthesis in Isolated Nuclei

Y Becker, Y Asher, Y Cohen, E Weinberg-Zahlering, J Shlomai

Antimicrob Agents Chemother. 1977 May;11(5):919-22.

PMID: 195514

Abstract:

Phosphonoacetic acid (PAA) inhibits the replication of herpes simplex virus in BSC-1 cells and the in vitro synthesis of deoxyribonucleic acid (DNA) in isolated nuclei. Phosphonopropionic acid at a concentration of 100 mug/ml had no effect on herpes simplex virus replication. PAA-resistant mutants were obtained at a rate of 1 in 10(4) plaque-forming units after 5-bromodeoxyuridine mutagenization of the virus. These mutants replicate in BSC-1 cells in the presence of 100 mug of PAA per ml and induce a PAA-resistant DNA polymerase that synthesizes DNA in vitro in the presence of PAA.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP4408780 Phosphonoacetic acid Phosphonoacetic acid 4408-78-0 Price
qrcode