Home
Resources
Publications
Photodynamic Therapy of Skin Cancer: Controlled Drug Delivery of 5-ALA and Its Esters

Photodynamic Therapy of Skin Cancer: Controlled Drug Delivery of 5-ALA and Its Esters

Renata Fonseca Vianna Lopez, Norbert Lange, Richard Guy, Maria Vitória Lopes Badra Bentley

Adv Drug Deliv Rev. 2004 Jan 13;56(1):77-94.

PMID: 14706446

Abstract:

Photodynamic therapy (PDT) is a tool for the treatment of certain cancerous and pre-cancerous conditions in dermatology. 5-Aminolevulinic acid (5-ALA) and simple derivatives thereof are the principal compounds used for this purpose. For optimal efficacy, the drug must be released at an appropriate rate from the formulation and penetrate the skin, ideally to reach the target tissue at a sufficiently high concentration. Because ALA is a polar, zwitterionic compound, its formulation in conventional topical vehicles, and its inherently poor skin permeability, poses important challenges for the pharmaceutical scientist. The synthesis of more lipophilic (e.g. ester) prodrugs of ALA resolves, in part, these issues but then demands that questions, related to biotransformation back to the parent 5-ALA and to stability, be addressed. The objective of this review, therefore, is to evaluate the state-of-the-art and identify those areas in which additional research is necessary.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP77479028	Aminolevulinic acid Related Compound A		77479-02-8	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: