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Photoresponsive, Water-Soluble Supramolecular Dendronized Polymer With Specific Lysosome-Targetable Bioimaging Application in Living Cells

Hang Li, Jie Wu, Jia-Fu Yin, Huan Wang, Yongquan Wu, Gui-Chao Kuang

Macromol Rapid Commun. 2019 Feb;40(3):e1800714.

PMID: 30408258

Abstract:

A novel photoresponsive, water-soluble supramolecular dendronized polymer (SDP) is prepared through a γ -cyclodextrin (γ -CD)-coumarin host-guest interaction. The supramolecular formation, photoresponsive process, and fluorescence properties are investigated by nuclear magnetic resonance (NMR) techniques and spectrometric measurements. Upon different-wavelength light irradiation, this supramolecular polymer undergoes noncovalent polymer and covalent polymer conversion due to coumarin cycloaddition and cleavage reactions. In addition, SDP for bioimaging in Michigan Cancer Foundation-7 (MCF-7) cells is performed and results show that the obtained SDP has good biocompatibility and is lysosome-targetable. This research enriches the field of supramolecular dendrimers and the photo-stimulation response material may have application prospects in organelle-targeting applications.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
LS741353 γ-Cyclodextrin polymer, soluble γ-Cyclodextrin polymer, soluble Price
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