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[Photothermal Effects of Metallic Carbon Nanotubes on Human Breast Cancer Cells]

[Photothermal Effects of Metallic Carbon Nanotubes on Human Breast Cancer Cells]

Jin Hou, Man Mi, Ming Wei, Wen-hui Yi

Yao Xue Xue Bao. 2015 Aug;50(8):980-5.

PMID: 26668997

Abstract:

SWNTs are a mixture of 1/3 metallic SWNTs (m-SWNTs) and 2/3 semiconducting SWNTs (s-SWNTs). It is desirable to separate the metallic SWNTs from the semi-conducting ones. In this study m-SWNTs was separated by using a poly[(m-phenylenevinylene)-alt-(p-phenylenevinylene)] (PmPV) derivative and used as photo-thermal media instead of SWNTs. The separation effects of m-SWNTs were evaluated by Raman spectra, molecular modeling and TEM images. The effects of m-SWNTs on MCF-7 cell proliferation and apoptosis were evaluated with MTT assay and flow cytometry, respectively. m-SWNTs were separated with high purity. A strong inhibition of MCF-7 cell growth was observed with the m-SWNTs under near-infrared (NIR) light irradiation. Our results will be helpful for the potential applications of m-SWNTs in clinical photothermal cancer therapy.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
LS772202	Poly[(m-phenylenevinylene)-alt-(2,5-dihexyloxy-p-phenylenevinylene)]			Price

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