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Phycocyanin Extracted From Oscillatoria Minima Show Antimicrobial, Algicidal, and Antiradical Activities: In-silico and In-vitro Analysis

Phycocyanin Extracted From Oscillatoria Minima Show Antimicrobial, Algicidal, and Antiradical Activities: In-silico and In-vitro Analysis

C V Vaishali, Abhimanyu Thakur, K C Latha, Gaurav Mishra, Kunal Singh, Parth Rathee, Anjali Ranjan

Antiinflamm Antiallergy Agents Med Chem. 2019 Apr 5.

PMID: 30950358

Abstract:

Background:
Phycocyanin is an algae-derived protein, which binds to pigment for harvesting light. It has been reported in various different species, including that of red algae, dinoflagellates, and cryptophyta. Importantly, phycocyanin has an enormous applications, including cosmetic colorant, food additive, biotechnology, diagnostics, fluorescence detection probe, anticancer agent, anti-inflammatory, immune enhancer, etc. In addition, several different algae were utilized for the isolation of C-PC, but most of the purification methods consist of several steps of crude extraction.
Aim:
To isolate C-PC from a new source of microalgae with better purity level and to evaluate its antimicrobial, algicidal, and antiradical activities.
Methods:
Biological activity, permeability, pharmacokinetics, and toxicity profile of C-PC was predicted by in-silico studies. C-PC was purified and isolated by using ammonium sulphate precipitation, ion-exchange chromatography, gel-filtration chromatography. C-PC was characterized by SDS-PAGE and elution profile (purity ratio) analysis. Antimicrobial and algicial activities of C-PC was evaluated by microtitre plate based assys. Antiradical activity of C-PC was evaluated by DPPH- and ABTS*+ radical scavenging assays.
Conclusion:
C-PC was extracted from Oscillatoria minima for the first time, followed by its quantitative as well qualitative evaluation, indicating a new alternative source of this important protein. Furthermore, the antimicrobial, algicidal, and antiradical activities of the isolated C-PC extract have been demonstrated by both in-silico as well as in-vitro methods.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42415835	ABTS Enhancer			Price

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