Home
Resources
Publications
Physical Characterization of Erythromycin: Anhydrate, Monohydrate, and Dihydrate Crystalline Solids

Physical Characterization of Erythromycin: Anhydrate, Monohydrate, and Dihydrate Crystalline Solids

P V Allen, P D Rahn, A C Sarapu, A J Vanderwielen

J Pharm Sci. 1978 Aug;67(8):1087-93.

PMID: 671242

Abstract:

Hot-stage microscopy, thermoanalytical methods, and X-ray powder diffraction were used to demonstrate that crystalline erythromycin dihydrate converts to the crystalline anhydrate via a noncrystalline intermediate. X-ray powder diffraction, IR spectral, thermogravimetric, and differential thermal analyses were used to characterize the monohydrate material. The flow interrupt technique, a procedure recently developed to deal with low surface area samples, was employed successfully in obtaining isotherms and specific surface areas for the monohydrate and anhydrate. The relative dissolution rates of the various hydrates were determined in an aqueous solution (0.01 M phosphate buffer, pH 7.5) at 37 degrees. The results showed a significant difference in the dissolution rate of the dihydrate compared to the monohydrate and anhydrate.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP59319721	Erythromycin A dihydrate		59319-72-1	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: