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Physicochemical and Release Properties of Pellets Coated With Kollicoat SR 30 D, a New Aqueous Polyvinyl Acetate Dispersion for Extended Release

Physicochemical and Release Properties of Pellets Coated With Kollicoat SR 30 D, a New Aqueous Polyvinyl Acetate Dispersion for Extended Release

A Dashevsky, K Wagner, K Kolter, R Bodmeier

Int J Pharm. 2005 Feb 16;290(1-2):15-23.

PMID: 15664126

Abstract:

Kollicoat SR 30 D is a new aqueous colloidal polyvinyl acetate dispersion used for extended release coatings. Kollicoat SR 30 D is stable against sedimentation, has a low viscosity (54 mPas) and a negative zeta potential of -23.2 mV because of the presence of the anionic surfactant, sodium dodecyl sulfate. Because of its low minimum film formation temperature (MFT = 18 degrees C), plasticizer addition and a thermal after-treatment (curing) of coated pellets was not required. Coated pellets showed no aging or curing effect. The rate of release could be easily adjusted by varying the coating level. A subcoating layer of the hydrophilic polymer, polyvinyl alcohol, between an ibuprofen-containing core and the Kollicoat SR coating prevented the diffusion of the lipophilic, low melting ibuprofen into the polymer coating during storage. The drug release from Kollicoat SR 30 D coated pellets was almost independent of the pH and ionic strength of release medium.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
CS31042860	Polyvinyl acetate dispersion			Price

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