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Physiological and Pharmacological Properties of 5-methoxytryptophol

Physiological and Pharmacological Properties of 5-methoxytryptophol

Mounir Ouzir, Nezha Bouhaddou, Hanane Khalki, Nouria Lakhdar-Ghazal

Expert Rev Endocrinol Metab. 2013 Jul;8(4):355-364.

PMID: 30736152

Abstract:

5-methoxytryptophol (5-ML) is a pineal indoleamine derived from serotonin shown to be biologically active in a number of species. This indolamine exhibits a circadian pattern synchronized with the day-night cycle with significant increases during daylight, already recognized in vertebrates. The multiplicity of physiological and endocrine functions of 5-ML is remarkable; it is involved in circadian rhythms, reproduction and sexual processes. Furthermore, a number of pharmacological benefits of 5-ML have been reported, including immunomodulatory, antitumor and antioxidative activities. However, the molecular mechanisms of these pharmacological effects remain unclear. The purpose of this article is to provide an overview on the general properties and physiological functions of 5-ML. An attempt has been made to fully document all studies performed using 5-ML. In addition, this article aims to gain insight into the current state of knowledge regarding pharmacological and therapeutic effects of this indoleamine.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP712094	5-Methoxytryptophol		712-09-4	Price

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