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Piroxicam and 5'-hydroxypiroxicam Kinetics Following Multiple Dose Administration of Piroxicam

Piroxicam and 5'-hydroxypiroxicam Kinetics Following Multiple Dose Administration of Piroxicam

C J Richardson, K L Blocka, S G Ross, R K Verbeeck

Eur J Clin Pharmacol. 1987;32(1):89-91.

PMID: 3582473

Abstract:

Piroxicam (20 mg once daily) was administered orally to six healthy young volunteers for 15 days. Trough steady-state levels of piroxicam and 5'-hydroxypiroxicam were 5.5 and 1.2 micrograms/ml, respectively. Piroxicam's plasma half-life (54.9 h) was significantly shorter than that of 5'-hydroxypiroxicam (70.5 h). Percent unbound piroxicam and 5'-hydroxypiroxicam in plasma at steady-state averaged 1.10 and 8.07 respectively. An average of 25.2% of the dose was recovered in urine as 5'-hydroxypiroxicam; approximately two-thirds (17.2%) in the form of the glucuronide conjugate. Average steady-state plasma levels (Css) of piroxicam (7.0 micrograms/ml) were significantly higher than predicted from a previously reported single dose study (5.3 micrograms/ml).

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP77459780	5′-Hydroxypiroxicam		77459-78-0	Price

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