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PK Evaluation of Fondaparinux Sodium for the Treatment of Thrombosis

PK Evaluation of Fondaparinux Sodium for the Treatment of Thrombosis

Xavier Delavenne, Paul Frappé, Paul Zufferey, Patrick Mismetti, Silvy Laporte, Laurent Bertoletti

Expert Opin Drug Metab Toxicol. 2014 Feb;10(2):269-77.

PMID: 24359588

Abstract:

Introduction:
Fondaparinux sodium (pentasaccharide) was the first of a new class of antithrombotic agents developed for the prevention and treatment of venous thromboembolism (VTE), blocking thrombin generation by selectively inhibiting factor Xa.
Areas covered:
This review focuses on the currently available information evaluating the pharmacokinetics, pharmacodynamics, clinical efficacy and safety of fondaparinux in the prevention and treatment of VTE and treatment of acute coronary syndromes (ACS).
Expert opinion:
Fondaparinux is an alternative to low-molecular-weight heparins (LMWH) for thromboprophylaxis in various clinical settings (major orthopedic surgery of the lower limbs, major abdominal surgery, immobilized medical patients at high risk of VTE), as well as for the treatment of VTE (deep venous thrombosis, pulmonary embolism). It is currently challenged, in the context of both surgical thromboprophylaxis and acute VTE treatment, by the new oral anticoagulants. Fondaparinux remains the sole drug validated in patients with isolated superficial vein thrombosis of the lower limbs, and at prophylactic doses is a good alternative to LMWH at anticoagulant doses for patients with ACS, especially those ineligible for percutaneous coronary intervention.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP114870030-C	Fondaparinux sodium		114870-03-0	Price

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