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PKC Inhibitors RO 31-8220 and Gö 6983 Enhance Epinephrine-Induced Platelet Aggregation in Catecholamine Hypo-Responsive Platelets by Enhancing Akt Phosphorylation

PKC Inhibitors RO 31-8220 and Gö 6983 Enhance Epinephrine-Induced Platelet Aggregation in Catecholamine Hypo-Responsive Platelets by Enhancing Akt Phosphorylation

Sun Young Kim, Sewoon Kim, Jeong Mi Kim, Eek-hoon Jho, Seonyang Park, Doyeun Oh, Hye Sook Yun-Choi

BMB Rep. 2011 Feb;44(2):140-5.

PMID: 21345315

Abstract:

Impaired responsiveness of platelets to epinephrine (epi) and other catecholamines (CA) has been reported in approximately 20% of the healthy Korean and Japanese populations. In the present study, platelet aggregation induced by epi was potentiated by RO 31-8220 (RO) or Gö 6983 (Gö). Phosphorylated Akt (p-Akt) was very low in epi-stimulated PRP from CA-hypo-responders (CA-HY), whereas it was detected in those from CA-good responders (CA-GR). RO and Gö increased p-Akt, one of the major downstream effectors of phosphoinositol-3 kinase (PI3K), in epi-stimulated PRP from both groups. Wortmannin, a PI3K inhibitor, attenuated the RO or Gö-induced potentiation of p-Akt in epi-stimulated PRP, suggesting positive effects for RO and Gö on PI3K. TXA(2) formation was increased by the addition of either RO or Gö in epi-stimulated platelets. The present data also suggest that impaired Akt phosphorylation may be responsible for epinephrine hypo-responsiveness of platelets.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP133053197-A	Gö 6983		133053-19-7	Price

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