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Plantamajoside Attenuates Inflammatory Response in LPS-stimulated Human Gingival Fibroblasts by Inhibiting PI3K/AKT Signaling Pathway

Plantamajoside Attenuates Inflammatory Response in LPS-stimulated Human Gingival Fibroblasts by Inhibiting PI3K/AKT Signaling Pathway

Fei Liu, Xin Huang, Jing-Jun He, Ci Song, Ling Peng, Ting Chen, Bu-Ling Wu

Microb Pathog. 2019 Feb;127:208-211.

PMID: 30476578

Abstract:

Periodontitis is an important inflammatory disease that often causes by periodontopathic bacteria. The present study, we tested the anti-inflammatory effects of plantamajoside on LPS-stimulated human gingival fibroblasts. Human gingival fibroblasts (HGFs) were stimulated with LPS from Porphyromonas gingivalis. Plantamajoside was administrated 1 h before LPS treatment. The results demonstrated that plantamajoside decreased the production of PGE2, NO, IL-6, and IL-8 in LPS-stimulated HGFs. LPS-induced NF-κB p65 and IκB phosphorylation were also suppressed by plantamajoside. Furthermore, plantamajoside inhibited LPS-induced PI3K and AKT phosphorylation. In conclusion, these results suggested that the mechanism of plantamajoside was through inhibiting PI3K/AKT signaling pathway, which lead to the inhibition of NF-κB activation and inflammatory response.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP104777686	Plantamajoside		104777-68-6	Price

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