Home
Resources
Publications
Plasma Concentrations and Relative Bioavailability of Naftidrofuryl From Different Salt Forms

Plasma Concentrations and Relative Bioavailability of Naftidrofuryl From Different Salt Forms

L M Walmsley, T Taylor, P A Wilkinson, R R Brodie, L F Chasseaud, V Alun-Jones, J O Hunter

Biopharm Drug Dispos. Jul-Aug 1986;7(4):327-34.

PMID: 3768488

Abstract:

The relative bioavailability of the vasodilator naftidrofuryl from formulations containing its oxalate or citrate salt has been estimated using a specific HPLC assay, and a less specific fluorimetric assay, to measure plasma drug concentrations. The conclusions of the study were the same irrespective of the assay employed. The relative rate, but not the extent, of bioavailability of naftidrofuryl from the citrate salt (peak 1096 ng ml-1 at 0.76 h) was marginally greater (p = 0.003) than that from the oxalate salt (peak 922 ng ml-1 at 0.94 h). The degree of intersubject variability was similar after administration of either salt form. The mean half-life of naftidrofuryl was 1.8 h and its mean residence time was 2.5 h.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP3200064	Nafronyl oxalate salt		3200-06-4	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: