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Plasma Demeclocycline Levels and Nephrotoxicity. Correlation in Hyponatremic Cirrhotic Patients

Plasma Demeclocycline Levels and Nephrotoxicity. Correlation in Hyponatremic Cirrhotic Patients

P D Miller, S L Linas, R W Schrier

JAMA. 1980 Jun 27;243(24):2513-5.

PMID: 6770106

Abstract:

In five hyponatremic, cirrhotic patients, demeclocycline hydrochloride was used to inhibit the hydroosmotic effect of vasopressin. In four, renal impairment developed during the 7 to 20 days of demeclocycline hydrochloride (900 to 1,200 mg/day) administration. In these four patients, creatinine clearance fell (72 to 20 mL/min, P less than .01) as BUN (12 to 47 mg/dl, P less than .02) and serum creatinine (0.9 to 4.2 mg/dl, P less than .01) levels rose. The azotemic effect of the drug could not be accounted for consistently by volume depletion secondary to its natriuretic effect. However, a close correlation between plasma demeclocycline levels and its azotemic effect was observed. We conclude that a nephrotoxic effect of demeclocycline severly limits its usefulness in treating hyponatremia in the cirrhotic patient.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP64733-B	Demeclocycline hydrochloride		64-73-3	Price

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